Prolonging Multi-Micronutrients Supplementation during Preconception Period Significantly Improves Pregnancy Outcomes: A Randomized Double Blind Community-based Trial
Sri Sumarmi*, Soenarnatalina Melaniani**, Kuntoro**,and Bambang Wirjatmadi*
*Faculty of Public Health Airlangga University, Surabaya, Indonesia
**Department of Biostatistic & Population Study, Faculty of Public Health, Airlangga University
*Faculty of Public Health Airlangga University, Surabaya, Indonesia
**Department of Biostatistic & Population Study, Faculty of Public Health, Airlangga University
Introduction :
Deficiency of micronutrients is common among women in reproductive age as well as among pregnant women. Supplementation of multi-micronutients to be view as a simpler nutrients intervention to improves pregnancy outcomes.
Objective:
This research focus to answer whether prolonging supplementation of multi micronutrients (MMN) during preconceptional period improve pregnancy outcomes compare to supplemantation of iron folic acid during pregnancy.
Materials & Methods:
A randomized double blind community-based trial had been conducted. Study subjects were randomly assigned into two group: Group I (MMN group) received mutlti micronutrient containing 14 micronutrients 2 other days during preconception, continue with daily dose during pregnancy. Group II (IFA group) received placebo during preconception period and continue with daily iron & folat during pregnancy. Total of 420 eliglible subjects were enrolled to meet approximately 190 pregnancy. The outcome variables are pregnancy outcomes, including weight gain, gestation age, birth size and placental weight. Social economic background, body mass index, vitamin A status, zinc status, and blood pressure also being assessed as base line data. Data was analyzed using independent-t test and general linear model to compare mean differentiation between MMN group and IFA group.
Results & Findings:
The preconception characteristic as initial data between two groups were not different, indicating that two groups are comparable ( Box’s M value = 44.95 and p = 0.65; Hotelling's Trace T2 value = 0.094, F = 1.098 and p = 0.371). Birth weight is significantly higher in MMN group (d= 285 g, p=0.000), lenght of birth is also significantly higher in MMN group (d= 1.7 cm, p=0.000), placental weight is higher in MMN group (d=65 g, p=0.011). But no significant difference of gestation age and wight gain between two groups.
Conclusion:
These findings imply that prolonging MMN supplementation 2-6 months prior to pregnancy provide significant added birth size compare to iron folic acid supplementation only during pregnancy, trough the development of pacental size but does not by increasing weight gain and prolonging gestation age.
Keywords: preconception nutrition, multi-micronutrients, pregnancy outcomes, birth size, placenta
Paper presented in Asian Congress of Nutrition, Yokohama Japan 14-19th May 2015
We are greatfully thank you to Indonesian Danone Institute Foundation for financial support
Deficiency of micronutrients is common among women in reproductive age as well as among pregnant women. Supplementation of multi-micronutients to be view as a simpler nutrients intervention to improves pregnancy outcomes.
Objective:
This research focus to answer whether prolonging supplementation of multi micronutrients (MMN) during preconceptional period improve pregnancy outcomes compare to supplemantation of iron folic acid during pregnancy.
Materials & Methods:
A randomized double blind community-based trial had been conducted. Study subjects were randomly assigned into two group: Group I (MMN group) received mutlti micronutrient containing 14 micronutrients 2 other days during preconception, continue with daily dose during pregnancy. Group II (IFA group) received placebo during preconception period and continue with daily iron & folat during pregnancy. Total of 420 eliglible subjects were enrolled to meet approximately 190 pregnancy. The outcome variables are pregnancy outcomes, including weight gain, gestation age, birth size and placental weight. Social economic background, body mass index, vitamin A status, zinc status, and blood pressure also being assessed as base line data. Data was analyzed using independent-t test and general linear model to compare mean differentiation between MMN group and IFA group.
Results & Findings:
The preconception characteristic as initial data between two groups were not different, indicating that two groups are comparable ( Box’s M value = 44.95 and p = 0.65; Hotelling's Trace T2 value = 0.094, F = 1.098 and p = 0.371). Birth weight is significantly higher in MMN group (d= 285 g, p=0.000), lenght of birth is also significantly higher in MMN group (d= 1.7 cm, p=0.000), placental weight is higher in MMN group (d=65 g, p=0.011). But no significant difference of gestation age and wight gain between two groups.
Conclusion:
These findings imply that prolonging MMN supplementation 2-6 months prior to pregnancy provide significant added birth size compare to iron folic acid supplementation only during pregnancy, trough the development of pacental size but does not by increasing weight gain and prolonging gestation age.
Keywords: preconception nutrition, multi-micronutrients, pregnancy outcomes, birth size, placenta
Paper presented in Asian Congress of Nutrition, Yokohama Japan 14-19th May 2015
We are greatfully thank you to Indonesian Danone Institute Foundation for financial support
