Efficacy Of Preconceptional Supplementation Of Multi-Micronutrients On Maternal Iron Status At Last Pregnancy
Sri Sumarmi*, Hamam Hadi**, W. Lestariana**, D.S. Nurdiati**, SN Melaniani*** and Bambang Wirjatmadi*
*Faculty of Public Health Airlangga University, Surabaya, Indonesia
**Faculty of Medicine Gajah Mada University, Yogyakarta, Indonesia
***Department of Biostatistic & Population Study, Faculty of Public Health, Airlangga University
*Faculty of Public Health Airlangga University, Surabaya, Indonesia
**Faculty of Medicine Gajah Mada University, Yogyakarta, Indonesia
***Department of Biostatistic & Population Study, Faculty of Public Health, Airlangga University
Introduction :
This research focus to evaluate the effect of multi micronutrients (MMN) supplementation during preconceptional period among the newly married women on improving maternal iron status.
Methods :
A randomized double blind community-based trial had been conducted at 9 selected sub district areas of Probolinggo District, East Java. Study subjects were randomly assigned into two group: Group I (MMN group) received mutlti micronutrient containing 14 micronutrients 2 other days during preconception, continue with daily dose during pregnancy. Group II (IFA group) received placebo during preconception period and continue with daily iron & folat during pregnancy. Total of 420 eliglible subjects were enrolled to meet approximately 120 pregnancy. The outcome variables is maternal iron status, represented by level of hemoglobin, serum ferritin, serum transferin receptor (sTfR) at last pregnancy. Social economic background, body mass index, vitamin A status, zinc status, and blood pressure also being assessed as base line data. Data was analyzed using general linear model to compare mean differentiation between MMN group and IFA group.
Results:
The preconception characteristic as initial data between two groups were not different, indicating that two groups are comparable ( Box’s M value = 44.95 and p = 0.65; Hotelling's Trace T2 value = 0.094, F = 1.098 and p = 0.371). There were no significant different on iron status at last pregnancy represent by concentration of hemoglobin, serum transferrin and soluble transferrin receptor (Box’s M value= 17.505, p = 0.014, Hotelling's Trace T2 value = 0.118, F = 1.341 and p = 0.277) between MMN group and IFA group.
Conclusion:
The efficacy of MMN supplementation during preconception on maternal iron status as effective as IFA. But the advantage of MMN compare to IFA, it improves process of erythropoeisis during last trimester by increasing iron mobilization which indicated by greater elevation of sTfR.
Keywords : preconception nutrition, multi-micronutrients, iron status, ferritin, soluble transferin receptor
Paper presented at APACPH 46th, Kuala Lumpur, Malaysia, October 2014
We greatfuly thank you to Danone Institute Indonesia for financial support
This research focus to evaluate the effect of multi micronutrients (MMN) supplementation during preconceptional period among the newly married women on improving maternal iron status.
Methods :
A randomized double blind community-based trial had been conducted at 9 selected sub district areas of Probolinggo District, East Java. Study subjects were randomly assigned into two group: Group I (MMN group) received mutlti micronutrient containing 14 micronutrients 2 other days during preconception, continue with daily dose during pregnancy. Group II (IFA group) received placebo during preconception period and continue with daily iron & folat during pregnancy. Total of 420 eliglible subjects were enrolled to meet approximately 120 pregnancy. The outcome variables is maternal iron status, represented by level of hemoglobin, serum ferritin, serum transferin receptor (sTfR) at last pregnancy. Social economic background, body mass index, vitamin A status, zinc status, and blood pressure also being assessed as base line data. Data was analyzed using general linear model to compare mean differentiation between MMN group and IFA group.
Results:
The preconception characteristic as initial data between two groups were not different, indicating that two groups are comparable ( Box’s M value = 44.95 and p = 0.65; Hotelling's Trace T2 value = 0.094, F = 1.098 and p = 0.371). There were no significant different on iron status at last pregnancy represent by concentration of hemoglobin, serum transferrin and soluble transferrin receptor (Box’s M value= 17.505, p = 0.014, Hotelling's Trace T2 value = 0.118, F = 1.341 and p = 0.277) between MMN group and IFA group.
Conclusion:
The efficacy of MMN supplementation during preconception on maternal iron status as effective as IFA. But the advantage of MMN compare to IFA, it improves process of erythropoeisis during last trimester by increasing iron mobilization which indicated by greater elevation of sTfR.
Keywords : preconception nutrition, multi-micronutrients, iron status, ferritin, soluble transferin receptor
Paper presented at APACPH 46th, Kuala Lumpur, Malaysia, October 2014
We greatfuly thank you to Danone Institute Indonesia for financial support
